OXIDATIVE STRESS, NITRIC OXIDE AND ITS RELATIONSHIP WITH PERI-IMPLANTITIS

Badea Florin Ciprian, Mitea (Gegiu) Gabriela, Raftu Gheorghe, Chele Nicolae, Suciu Felicia, Caraiane Aureliana

Abstract:

Introduction The study aims to evaluate oxidative stress by quantifying nitric oxide (NO), as well as identifying the possible correlation between NO and clinical parameters in peri-implantitis in order to optimize the diagnosis and monitoring of this condition. Material and method The study was carried out on three groups of patients with dental implants, selected after applying the established inclusion and exclusion criteria, as follows: patients with a favorable evolution, patients with mucositis and patients with peri-implantitis. The evaluation of salivary (NO) was done after 4 and 12 weeks after the insertion of dental implants using NO strips (Berkeley test strip, USA). Results of the present study show that there are statistically significant differences regarding salivary NO values after both moments of quantification between the groups of patients with favorable evolution and patients with peri-implantitis (p=0.0001; 0.0003); there are no statistically significant differences between the groups of patients with mucositis and peri-implantitis for both moments of salivary NO determination. Also, there is a correlation between NO values and clinical parameters, respectively the depth of the peri-implant groove) for patients with mucositis (r=0.676; r=0.725) and peri-implantitis (r=0.650; r=0.844) for both determination moments. Conclusions of the study are that NO can be considered a marker for estimating the inflammatory process in the context of peri-implantitis. The facility with which NO is determined in saliva, recommends that the test be used in the dental office as a biomarker in the diagnosis and monitoring of peri-implantitis.

DOI : 10.62610/RJOR.2025.3.17.30