IMPACT OF SURFACE MORPHOLOGY OF A MG-ZN-ZR-CA ALLOY ON OSTEOBLAST VIABILITY AND ATTACHMENT

Radu Emil Hendea, Mărioara Moldovan, Doina Stanciu, Doina Raducanu, Vasile Danut Cojocaru, Radu Septimiu Câmpian, Alexandru-Victor Burde

ABSTRACT

Aim of the study The objective of this study is to evaluate the biocompatibility and osteointegration potential of the novel Mg-10Zn-0.8Ca-0.5Zr alloy for use in biodegradable orthopaedic and maxillofacial implants. Materials and methods: The Mg-10Zn-0.8Ca-0.5Zr alloy was produced using mechanical alloying (MA) and processed by additive manufacturing, using Selective Laser Melting (SLM) technique. Its biocompatibility and cytotoxic effects were assessed by exposing MG63 osteoblast-like cells to the alloy and analysing cell viability and morphology through MTT assays and SEM imaging, enabling a thorough evaluation of cell-alloy surface interactions and microstructure. Results Mg-10Zn-0.8Ca-0.5Zr alloy demonstrated high cell viability and favourable osteoblast morphology, indicating excellent biocompatibility. SEM imaging revealed that the alloy’s surface morphology and roughness positively influenced cellular behaviour, promoting adhesion and proliferation. Comparison between the novel alloy and a commercially available titanium screw indicated the superior biocompatibility of the Mg-10Zn-0.8Ca-0.5Zr alloy. Conclusions The Mg-10Zn-0.8Ca-0.5Zr alloy demonstrates promising potential for use in bone reconstruction, given its biocompatibility and surface characteristics conducive to osteointegration.

DOI : 10.62610/RJOR.2025.3.17.29