Alexandra-Camelia Pogacian-Maier, Radu Septimiu Campian, Alexandru Mester, Andra Piciu
ABSTRACT
Background and Aim: Periodontal disease and hepatitis C virus (HCV) infection are chronic conditions with systemic and oral health implications. This study aimed to evaluate the effects of non-surgical periodontal treatment combined with direct-acting antiviral (DAA) therapy in HCV patients. Materials and Methods: A prospective interventional study was conducted with 80 participants divided into four groups based on periodontal and HCV status. Periodontal parameters (probing depth (PD), clinical attachment loss (CAL), oral hygiene index (OHI), and bleeding on probing (BOP)) were measured at baseline, 3 months, and 6 months. Results: Significant improvements in OHI and BOP were observed across all groups, particularly in HCV patients receiving DAA therapy combined with periodontal treatment. PD and CAL values remained stable, suggesting effective management of periodontal disease progression. Conclusion: This study indicates the importance of an integrated approach to managing HCV and periodontal disease, highlighting the synergistic effects of DAA therapy and non-surgical periodontal treatment.
DOI : 10.62610/RJOR.2025.1.17.24
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