Alexandra Vornicu, Bogdan Filip, Nicolae Ioanid, Bogdan Gafton, Raluca Pleșca, Cristina Terinte, Iulian Prutianu, Andrei-Ionuț Cucu, Cristina-Gena Dascălu, Dragos-Viorel Scripcariu, Viorel Scripcariu, Danisia Haba, Loredana Liliana Hurjui
ABSTRACT
This study aimed to explore the imaging features, immunohistochemical profiles, and molecular characteristics of brain and mandibular metastases stemming from breast cancer (BC). Introduction: Brain metastases (BM) represent a common and devastating manifestation of BC. BM are particularly prevalent in BC phenotypes expressing human epidermal growth factor receptor 2 (HER2-positive) marker and triple-negative subtypes and often occur following metastatic spread to various sites. BM represent a major contributor to morbidity and mortality in individuals with metastatic BC. Material and Methods: A retrospective analysis was conducted on 47 patients diagnosed with both brain metastases and facial masses as sites of metastases. The results predominantly indicated invasive ductal carcinoma, with a slightly higher incidence in cases affecting the right breast. In most cases, the intervention performed was a modified Madden mastectomy. Discussions: Our study highlights the greater aggressiveness of BC in younger women and the marked heterogeneity in tumor response to oncological treatment. Conclusions: Facial mass involvement resulting from metastases from BC cases is rare, but signifies the increased aggressiveness of these tumors. Further studies on larger patient cohorts are necessary to better understand the etiopathogenic mechanisms underlying the development of this type of metastasis.
DOI : 10.62610/RJOR.2025.1.17.37
Loading...
Reload document 
Open in new tab