Carmen Amititeloaie, Marcel Costuleanu
ABSTRACT
Aim of the study Exosomes are small extracellular vesicles containing genetic material, proteins and lipids. They function as potent signaling molecules between cancer cells and the surrounding ones, contributing to the formation of the tumor microenvironment (TME). Exosomes derived from tumor and stromal cells are involved in all stages of cancer progression and play a crucial role in the development of resistance to treatments. Also, because of their function as mediators in cell-to-cell communication, they constitute an essential part of the therapeutic resistance mechanism associated with TME. In this article, we aimed to analyze the current techniques for the isolation and profiling of exosomes, as well as their contribution to TME interactions and therapeutic resistance. We also discuss the emerging clinical applications of exosomes, considering them as biomarkers, direct therapeutic targets, and artificial nanocarriers. A deep understanding of the TME requires a detailed analysis of exosomes and their contents, which is a promising direction for the development of effective clinical applications.
DOI : 10.62610/RJOR.2025.1.17.65
Loading...
Reload document 
Open in new tab