Erdogan Elvis Șachir, Cristina Gabriela Pușcașu, Gheorghe Raftu, Victoria Badea, Cristina Bartok-Nicolae, Claudia Elena Sin, Steliana Gabriela Buștiuc, Aureliana Caraiane
ABSTRACT
Aim of the study: This study investigates the antibacterial efficacy and cytotoxicity of a hydroalcoholic extract derived from Epilobium parviflorum Schreb for potential use in endodontic therapy. Materials and methods: The extract was prepared through dehydration, yielding a concentration of 10 mg/mL, which was subsequently assessed for its bioactive compounds, revealing a significant increase in polyphenol concentration. Cytotoxicity was evaluated using the MTT assay on L929 fibroblast cell cultures, where concentrations below 0.2 mg/mL demonstrated no cytotoxic effects. In contrast, higher concentrations resulted in decreased cell viability, highlighting the extract’s selective toxicity profile. Results The absence of cytotoxicity at lower concentrations supports its potential application as an alternative to traditional endodontic irrigants, which often exhibit significant cytotoxic effects. Recent studies underscore the importance of biocompatibility in dental treatments, reinforcing the notion that plant-derived solutions can effectively balance antimicrobial efficacy and cellular safety. This research aligns with growing evidence advocating for the integration of herbal extracts in dental practice, promoting safer treatment alternatives that enhance patient outcomes without compromising tissue integrity. Conclusions Overall, this study contributes to the understanding of herbal applications in dentistry, emphasizing the need for further exploration of natural compounds in therapeutic settings.
DOI : 10.62610/RJOR.2025.3.17.16
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