Introduction Class III Angle malocclusion is a sagittal plane dento-maxillary anomaly characterized by mesial molar relationship and reverse frontal offset. Clinical manifestations in childhood class III Angle malocclusion are frequently associated with various disturbances of muscle and neurophysiological activity. There are many published studies in the literature on the alteration of the muscles of the stomatognathic system in orthodontic pathologies. Aim of the study To determine the functional adaptive activity of the muscles of the stomatognathic system in children associated with Angle class III malocclusion under the influence of orthodontic treatment. Material and methods The study included 58 children, who were divided into 2 groups, statistically equivalent according to age, gender, facial development, balanced psycho-emotional state. Patients in both groups were investigated by clinical and paraclinical examination methodology which was completed by neuro-physiological examination. The study was based on clinical and paraclinical examination data, methods of diagnosis and orthodontic treatment of Angle class III malocclusion, treated in the orthodontic department and in the dental clinic S.C ” Orto-Dental”. Electro-neurophysiological investigations were conducted in the Neuronova University Clinic, Republic of Moldova. These technologies have been applied with the investigation of surface electromyography in healthy children and children with Angle class III malocclusion, in conditions of application of different samples (chewing, forced biting, swallowing). Results. Our results demonstrated that the degree of functional maladaptation in the masticatory muscles can be assessed according to 3 criteria: 1) the intensity of functional and adaptive process disturbances; 2) the degree of asymmetry of the functional interaction processes of the muscles; 3) integral indices of functional-adaptive correlation.