Nicuta Manolache, Gabriela Stoleriu, Ionela Daniela Ferțu, Steliana Simona Tudor, Mihail-Alexandru Badea, Filip-Ciubotaru Florina Mihaela
ABSTRACT
Background: Chronic venous disease (CVD) is a prevalent vascular disorder, primarily characterized by venous hypertension, valvular insufficiency, and ulceration. Emerging evidence suggests a potential association between CVD and cardiovascular diseases (CVDs), including hypertension, ischemic heart disease, and heart failure. This study investigates whether CVD serves as an independent risk factor for CVDs by assessing their prevalence and clinical overlap. Methods: two complementary analyses were conducted. The first examined the prevalence of CVDs in 536 patients with CVD, while the second assessed CVD in 125 inpatients with CVDs. Patients were classified using CEAP criteria, and data analysis included multivariate regression models adjusted for cardiovascular risk factors. Results: among CVD patients, 49.66% also had CVDs, with hypertension (31.2%) being the most common. CVD prevalence increased with disease severity, from 29.5% in CEAP C0-C2 to 70.5% in C3-C6. In cardiovascular patients, 70.4% exhibited CVD, with hypertension (78.2%) and ischemic heart disease (70.5%) as leading comorbidities. Conclusions: the study highlights a strong epidemiological link between CVD and CVDs, emphasizing the role of endothelial dysfunction, chronic inflammation, and hemodynamic alterations in their coexistence. Early screening and integrated vascular management are essential, and future longitudinal studies are needed to establish causality and develop targeted therapeutic approaches.
DOI : 10.62610/RJOR.2025.1.17.59
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