Luiza Camelia Nechita, Luciana Carmen Nitoi, Amin Bazyani, Ana Maria Zaharescu, Ciprian Adrian Dinu
Abstract
Atherosclerosis is one of the leading causes of morbidity and mortality worldwide, with chronic inflammation playing a central role in its pathogenesis. Increasing evidence suggests that oral health, particularly the presence of periodontal disease, is closely linked to the progression of atherosclerosis and an increased cardiovascular risk. The underlying mechanisms include the dissemination of oral bacteria into the systemic circulation, activation of the inflammatory response, and impairment of endothelial function, which promote atherosclerotic plaque formation and acute cardiovascular events. Studies indicate that patients with periodontitis exhibit elevated levels of inflammatory proteins such as C-reactive protein and interleukin-6, highlighting systemic inflammation as a key link between these two conditions. Moreover, periodontal treatments appear to have beneficial effects on inflammatory markers and vascular health, suggesting a potential therapeutic role. In this context, a multidisciplinary approach incorporating dental screening into cardiovascular prevention and fostering collaboration between dentists and cardiologists could improve patient outcomes. Integrating oral health into current medical strategies may represent a crucial step in reducing cardiovascular risk and optimizing atherosclerosis prevention.
DOI : 10.62610/RJOR.2025.1.17.85
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