Emil Ceban, Kamel Earar, Luiza Camelia Nechita, Solomon Oleg, Anamaria Zaharescu, Viorel Jinga
Abstract
Metronidazole is a widely used antimicrobial agent effective against anaerobic bacteria and protozoa, characterized by rapid absorption, extensive tissue distribution, and significant hepatic metabolism. Its active metabolites contribute to both its antimicrobial efficacy and notable side effects, such as urine discoloration. While this side effect is benign, it can lead to patient concern or unnecessary clinical investigations if not properly addressed. This review explores the pharmacokinetic and pharmacodynamic properties of metronidazole, highlighting its absorption, metabolism, elimination, and drug interactions. Key clinical considerations include its use in special populations, such as pregnant or breastfeeding patients, and the need for dose adjustments in hepatic or renal impairment. Additionally, the review compares urine discoloration associated with metronidazole to similar effects caused by other drugs, emphasizing the importance of patient education. Future research directions include identifying biomarkers for distinguishing medication-induced effects from pathological conditions and optimizing therapeutic protocols through personalized medicine.
DOI : 10.62610/RJOR.2025.1.17.90
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