Elitsa Sabeva-Peeva, Mariya Miteva-Hristova, Ivaylo Hristov
DOI : 10.62610/RJOR.2025.2.17.11
ABSTRACT
Aim of the study Every day in their practice, dentists are introduced to new, modern biological materials. Some of these materials have managed to overcome some of the shortcomings of those used to date and are becoming commercially available as an alternative regenerative option. Others, however, are disappearing very quickly due to their unremarkable effectiveness. At the same time as these biomaterial developments, new regenerative approaches are continually being proposed to provide predictable, post-operative results. The purpose of this systematic review is to summarize which methods involving various combinations of guided tissue regeneration (GTR), bone grafts and platelet-rich plasma (PRP) have been most preferred in the treatment of vertical bone defects. Materials and methods. Web of Science, Scopus and PubMed were the electronic databases that were screened for publications related to the topic of this study for the period from 1 January 2010 to 1 January 2025.) Results Twenty-three studies were included in this systematic review. It presents a summary of the most preferred surgical approaches combining guided tissue regeneration, bone grafts and platelet-rich plasma in the treatment of vertical bone defects and analyses their efficacy according to well-defined investigated parameters – probing depth, clinical level of attachment and bone filling. Conclusions It became clear that the most used combination method among the sought after is the one in which bone-repair materials and platelet-rich plasma are jointly applied. It would be good for future studies to pay more attention to other combined techniques including guided tissue regeneration, bone grafts and platelet-rich plasma to conclude whether they would be alternative methods in regenerative periodontal therapy.
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