Vlad Robert-Alexandru, Pintea Andrada, Antonoaea Paula, Rédai Emöke-Margit, Cotoi Cornelia-Titiana, Bîrsan Magdalena, Ghica Dragoș Cătălin, Ciurba Adriana
ABSTRACT
Orodispersible films (ODFs) represent a fast-dissolving dosage formulation designed for easy administration without water. Excipients play pivotal roles in ODF formulation, encompassing film-forming agents, plasticizers, sweeteners, flavoring agents, disintegrants, and stabilizers. Concentrations of excipients vary, each exhibiting a defined range to optimize film properties. This review analyzes excipient roles, concentrations, and their impact on ODF development through two main different methods represented by solvent-casting and electrospinning methods with the solvent-casting method being the one that can be used at a larger scale compared to the electrospinning method where the flow-rate influencing the yield. Also, the solvent-casting method is cheaper compared to the electrospinning method, but the latter outlines the advantage of the possibility to be used for thermosensitive active ingredients. It highlights the importance of excipient selection and optimization for effective oral drug delivery and the challenges that might occur during the manufacturing and analysis steps.
DOI : 10.62610/RJOR.2025.1.17.55
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