BRIDGING THE GAP AND FIGHTING INFECTION: INNOVATIVE BIOMATERIALS IN THE BATTLE AGAINST OSTEOMYELITIS

Maria-Cristina Moraru, Aurora Antoniac, Alexandra-Iulia Dreanca, Stefan Dudescu, Alexandru-Victor Burde, Andreea-Codruta Novac, Veronica Manescu (Paltanea), Elena Popescu, Iuliana Corneschi, Iulian Antoniac, Marius Manole, Bogdan Sevastre

DOI : 10.62610/RJOR.2025.2.17.70

ABSTRACT

Aim of the Study: This review investigates the use of antibiotic-loaded biomaterials in the treatment of osteomyelitis, with a focus on preclinical studies involving rat models. These models are widely used to assess local drug delivery, antibacterial effectiveness, and bone regeneration. Materials and Methods: A literature search was conducted to identify in vivo studies from the past decade using rat models of osteomyelitis treated with antibiotic-loaded biomaterials. Studies were analyzed based on biomaterial types, infection models, assessment methods, and treatment outcomes.Results: Rat models provide a reliable platform for evaluating the antimicrobial and regenerative effects of biomaterials. Materials such as calcium sulfate and mesoporous glass demonstrated promising results in localized antibiotic delivery and bone healing. Conclusions:
Antibiotic-loaded biomaterials show strong potential in osteomyelitis management. Rat models play a key role in their development and preclinical validation. Further research should focus on multifunctional scaffolds and standardized testing protocols to improve clinical translation.