Magdalena Rusu-Negraia, Dorin Ioan Cocoș, Antoanela Magdalena Covaci, Kamel Earar
DOI : 10.62610/RJOR.2026.2.18.21
Abstract
Biodentine is a bioactive hydraulic calcium silicate–based material developed as a dentine substitute to overcome limitations associated with calcium hydroxide liners and mineral trioxide aggregate–based cements. This narrative review summarizes current evidence regarding its physicochemical properties, biological activity, interfacial behavior, adhesive performance, and clinical applications in restorative dentistry and endodontics. Biodentine is characterized by accelerated hydration, zirconium oxide–based radiopacity, progressive maturation, favorable dimensional stability, and mechanical properties approaching those of natural dentine. Its bioactivity is mediated by calcium and hydroxyl ion release, alkaline pH, mineral precipitation, and stimulation of pathways involved in pulp repair, odontogenic differentiation, and biomineralization. At the dentine–material interface, Biodentine demonstrates direct adaptation and ionic interaction, although interfacial morphology is influenced by maturation, placement technique, and analytical methodology. Clinically, it has shown favorable outcomes in vital pulp therapy, deep caries management, temporary coronal restoration, dentine replacement, perforation repair, apexification, and root-end filling. Its performance nevertheless depends on isolation, irrigation protocols, sufficient maturation, restorative timing, and case selection. Current evidence supports Biodentine as a clinically relevant bioactive dentine substitute, although further standardized long-term studies are required.
Loading...
Reload document 
Open in new tab