Boca Antonia, Cosmina Ioana Bondor, Sanda Ileana Cîmpean, Ioana Bâldea, Sebastian Candrea, SALIVAGES Project group, Aranka Ilea
DOI : 10.62610/RJOR.2025.2.17.15
ABSTRACT
Background: This study aimed to assess the relationship between the levels of advanced glycation end products (AGEs), specifically Nε-carboxymethyl-lysine (CML), in the pulpar and periapical tissues of patients with chronic apical periodontitis (CAP) and their association with oxidative stress markers and other clinical parameters.
Methods: Seventy-three patients diagnosed with Chronic apical periodontitis (CAP) were recruited from the Oral Rehabilitation and Prosthodontic Departments, Faculty of Dentistry, and the Regional Diabetes Center in Cluj-Napoca, Romania, between 2018 and 2019. Fifteen patients required tooth extractions due to severe CAP-related root damage. The extracted teeth were sectioned, and tissue samples were collected from both the pulp and periapical regions. Blood samples were drawn to measure various biochemical parameters and inflammatory markers. Stimulated saliva was also collected to assess oxidative stress markers. CML and other AGEs were quantified in plasma and saliva using liquid chromatography-mass spectrometry (LC-MS/MS).
Results: The study revealed significant positive correlations between CML levels in pulpal and periapical tissues and oxidative stress markers in saliva, including total oxidative status (TOS) and oxidative stress index (OSI).
Conclusions: The findings suggest that CML levels in dental tissues are linked to oxidative stress, as reflected in saliva biomarkers. These results support the potential use of salivary markers as non-invasive indicators of oxidative stress and CAP progression. Further studies with larger sample sizes are needed to confirm these findings and explore their clinical implications.
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