Sidharth Erramshetty, Jayashri Prabakar, Meignana Arumugham Indiran, Rajesh Kumar Shanmugham
DOI : 10.6261/RJOR.2024.3.16.26
Abstract
Introduction: Oral ulcers are a common, painful condition with limited effective treatment options. This study explores the potential of a novel herbal gel formulation using Lagenaria siceraria (Bottle gourd) fortified with honey as a treatment for oral ulcers.
Materials and methods: The gel’s antimicrobial and cytotoxic activities were evaluated in vitro. Lagenaria siceraria was extracted and combined with honey to create the gel, which was tested against three bacterial strains: Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using agar well diffusion and time-kill curve assays.
Results: The results demonstrated significant antimicrobial activity, with the highest inhibition observed in P. aeruginosa. Cytotoxicity was assessed using nauplii fish, showing minimal adverse effects at lower concentrations.
Conclusion: This study suggests that the Lagenaria siceraria and honey gel could be a promising, natural alternative for managing oral ulcers, combining efficacy with low cytotoxicity. Further studies are recommended to validate these findings and explore the potential for clinical application.
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